Ketamine therapy is quickly becoming a groundbreaking treatment for depression, especially for those with treatment-resistant depression. Unlike traditional antidepressants, ketamine works by targeting the glutamate system, promoting neuroplasticity, and stimulating new neural connections in the brain. When combined with talk therapy, it enhances emotional healing and offers rapid symptom relief. In this post, I’ll explain how ketamine works, its origins in medicine, and why pairing it with psychotherapy is one of the most effective treatments for depression today.